4-Cyclopropylmethyl-O-methyl Mycophenolic Acid

Ref. TR-C989240

Product Information

• Name: 4-Cyclopropylmethyl-O-methyl Mycophenolic Acid
• Synonyms: Methyl 3-(2-((4-Hydroxy-6-methoxy-7-methyl-3-oxo-1,3-dihydroisobenzofuran-5-yl)methyl)-1-methylcyclopropyl)propanoate
• Brand: TRC
• Description: Applications 4-Cyclopropylmethyl-O-methyl Mycophenolic Acid is an intermediate in the synthesis of 4-Cyclopropylmethyl-O-glucuronide Mycophenolic Acid (C989235), an analogue of Mycophenolic Acid (M831500), an antibiotic produced by Penicillium brevi-compactum, P. Stoloniferum and related spp. A selective inhibitor of lymphocyte proliferation by blocking inosine monophosphate dehydrogenase, an enzyme involved in the de novo synthesis of purine nucleotides.References Senda, M., et al.: Transplantation, 60, 1143 (1995); Nimmesgern, E., et al.: J. Biol. Chem., 271, 19421 (1996); Gummert, J.F., et al.: J. Pharmacol. Exp. Ther., 291, 1100 (1999)

Chemical properties

• Molecular weight: 348.39
• Formula: C₁₉H₂₄O₆
• Color/Form: Neat
• InChI: InChI=1S/C19H24O6/c1-10-13-9-25-18(22)15(13)16(21)12(17(10)24-4)7-11-8-19(11,2)6-5-14(20)23-3/h11,21H,5-9H2,1-4H3
• InChI key: InChIKey=ILMOANMCMVSGAC-UHFFFAOYSA-N
• SMILES: COC(=O)CCC1(C)CC1Cc1c(O)c2c(c(C)c1OC)COC2=O