Cyclopentenylcytosine-5'-triphosphate Triethylamine Salt

CAS: 118045-71-9

Ref. TR-C989805

Product Information

• Name: Cyclopentenylcytosine-5'-triphosphate Triethylamine Salt
• Synonyms: Triphosphoric Acid P-[[(3R,4S,5R)-3-(4-Amino-2-oxo-1(2H)-pyrimidinyl)-4,5-dihydroxy-1-cyclopenten-1-yl]methyl] Ester Triethylamine Salt, CPEC-TP Triethylamine Salt
• Brand: TRC

Description

Applications Cyclopentenylcytosine-5'-triphosphate is the active metabolite of Cyclopentenylcytosine (C989800); a nucleoside analog which exhibits antineoplastic activity against several murine and human tumors in tissue culture. Cyclopentenylcytosine-5'-triphosphate is also an inhibitor of cytidine-5'-triphosphate (CTP) synthetase causing a rapid depletion of intracellular cytidine nucleotides.
References Agbaria, R., et al.: Anal. Biochem., 213, 90 (1993); Agbaria, R., et al.: Oncol. Res., 9, 111 (1997); Bierau, J., et al.: Adv. Exp. Med. Biol., 486, 277 (2000)

Chemical properties

• Molecular weight: 479.17 + x(101.19)
• Formula: C₁₀H₁₆N₃O₁₃P₃•xC₆H₁₅N
• Color/Form: Neat
• InChI: InChI=1S/C10H16N3O13P3.C6H15N/c11-7-1-2-13(10(16)12-7)6-3-5(8(14)9(6)15)4-24-28(20,21)26-29(22,23)25-27(17,18)19;1-4-7(5-2)6-3/h1-3,6,8-9,14-15H,4H2,(H,20,21)(H,22,23)(H2,11,12,16)(H2,17,18,19);4-6H2,1-3H3/t6-,8?,9+;/m1./s1
• InChI key: InChIKey=XLFBUCNIZKGIGT-TXAGBKTCSA-N
• SMILES: CCN(CC)CC.Nc1ccn([C@@H]2C=C(COP(=O)(O)OP(=O)(O)OP(=O)(O)O)C(O)C2O)c(=O)n1