(1S,​2S)​-1,​2-​Cyclopropanedicarbox​ylic Acid 1,​2-​Diethyl Ester

CAS: 889461-57-8

Ref. TR-C990413

Product Information

• Name: (1S,​2S)​-1,​2-​Cyclopropanedicarbox​ylic Acid 1,​2-​Diethyl Ester
• Synonyms: (1S,2S)-Diethyl cyclopropane-1,2-dicarboxylate

Description

Applications (1S,​2S)​-1,​2-​Cyclopropanedicarbox​ylic Acid 1,​2-​Diethyl Ester is an intermediate in synthesizing (O846925), (2S,3S)-2,3-Oxiranedicarboxylic Acid Monoethyl Ester is used in the synthesis of aza-peptidyl inhibitors of lysosomal asparaginyl endopeptidase, legumain. Also used in the synthesis of irreversible epidermal growth factor receptor inhibitors and probes for cathespins.
References Lee, J. et al.: Bioorg. Med. Chem. Lett., 22, 1340 (2012); Carmi, C. et al.: J. Med. Chem., 53, 2038 (2010); Hillaert, U. et al.: Angew. Chem. Int. Ed., 48, 1629 (2009);

• Brand: TRC

Chemical properties

• Molecular weight: 186.205
• Formula: C₉H₁₄O₄
• Color/Form: Neat
• InChI: InChI=1S/C9H14O4/c1-3-12-8(10)6-5-7(6)9(11)13-4-2/h6-7H,3-5H2,1-2H3/t6-,7-/m0/s1
• InChI key: InChIKey=SXLDHZFJMXLFJU-BQBZGAKWSA-N
• SMILES: CCOC(=O)[C@H]1C[C@@H]1C(=O)OCC