Estimated delivery in United States, on Wednesday 15 Jan 2025
Product Information
Name:
Dabrafenib Mesylate
Controlled Product
Synonyms:
- Benzenesulfonamide
- N-[3-[5-(2-amino-4-pyrimidinyl)-2-(1,1-dimethylethyl)-4-thiazolyl]-2-fluorophenyl]-2,6-difluoro-
- methanesulfonate (1:1)
- GSK 2118436 methanesulfonate salt
- GSK 2118436B
- N-[3-[5-(2-Aminopyrimidin-4-yl)-2-tert-butyl-1,3-thiazol-4-yl]-2-fluorophenyl]-2,6-difluorobenzenesulfonamide methanesulfonic acid
- GSK 2118436B
Description:
Stability Hygroscopic
Applications Dabrafenib is an inhibitor of mutated BRAF kinase and has clinical activity with a manageable safety profile in clinical trials of phase 1 and 2 in patients with BRAF(V600)-mutated metastatic melanoma.
References Hauschild, A., et al.: Lancet, 380, 358 (2012); Falchook, G.S., et al.: Lancet, 379, 1893 (2012); Ascierto, P.A., et al.: J. Clin. Oncol., 31, 3205 (2013)
Notice:
Our products are intended for lab use only. For any other use, please contact us.
Brand:
TRC
Long term storage:
Notes:
Chemical properties
Molecular weight:
615.67
Formula:
C23H20F3N5O2S2·CH4O3S
Color/Form:
White
InChI:
InChI=1S/C23H20F3N5O2S2.CH4O3S/c1-23(2,3)21-30-18(19(34-21)16-10-11-28-22(27)29-16)12-6-4-9-15(17(12)26)31-35(32,33)20-13(24)7-5-8-14(20)25;1-5(2,3)4/h4-11,31H,1-3H3,(H2,27,28,29);1H3,(H,2,3,4)
InChI key:
InChIKey=YKGMKSIHIVVYKY-UHFFFAOYSA-N
SMILES:
CC(C)(C)c1nc(-c2cccc(NS(=O)(=O)c3c(F)cccc3F)c2F)c(-c2ccnc(N)n2)s1.CS(=O)(=O)O
MDL:
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EINECS:
Merck:
HS code:
Technical inquiry about: TR-D101005 Dabrafenib Mesylate
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