Diphenylmethyl (6R,7R)-3-(Chloromethyl)-8-oxo-7-[(phenylmethylene)amino]-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Ester

CAS: 109883-94-5

Ref. TR-D107565

Product Information

• Name: Diphenylmethyl (6R,7R)-3-(Chloromethyl)-8-oxo-7-[(phenylmethylene)amino]-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Ester
• Synonyms: Diphenylmethyl (6R-trans)-(6R,7R)-3-(Chloromethyl)-8-oxo-7-[(phenylmethylene)amino]-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Ester
• Brand: TRC

Description

Applications Diphenylmethyl (6R,7R)-3-(Chloromethyl)-8-oxo-7-[(phenylmethylene)amino]-5-Thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic Acid Ester is an intermediate used in the synthesis of 1-[[(6R,7R)-7-Amino-2-carboxy-8-oxo-5-thia-1-azabicyclo[4.2.0]oct-2-en-3-yl]methyl]-1-methylpyrrolidinium Chloride (A603160), which is an impurity in the synthesis of Cefepime (C242750), a semisynthetic, fourth generation cephalosporin antibiotic. Antibacterial.
References Khan, N.J., et al.: Antimicrob. Agents Chemother., 26, 585 (1984), Naito, T., et al.: J. Antibiot., 39, 1092 (1986), Okamoto, M.P., et al.: Clin. Pharmacokinet., 25, 88 (1993),

Chemical properties

• Molecular weight: 503.012
• Formula: C₂₈H₂₃ClN₂O₃S
• Color/Form: Neat
• InChI: InChI=1S/C28H23ClN2O3S/c29-16-22-18-35-27-23(30-17-19-10-4-1-5-11-19)26(32)31(27)24(22)28(33)34-25(20-12-6-2-7-13-20)21-14-8-3-9-15-21/h1-15,17,23,25,27H,16,18H2/b30-17+/t23-,27-/m1/s1
• InChI key: InChIKey=CYPVIHKHWSGIIK-CCVCDZMCSA-N
• SMILES: O=C(OC(c1ccccc1)c1ccccc1)C1=C(CCl)CS[C@@H]2[C@H](/N=C/c3ccccc3)C(=O)N12