Product Information
Name:Deshydroxy Tarcolimus
Controlled Product
Synonyms:
- Tarcolimus Impurity IX
Brand:TRC
Description:Applications Deshydroxy Tarcolimus is an impurity of Tacrolimus(F370000). Tacrolimus is an immunosuppressant that blocks T cell proliferation in vitro by inhibiting the generation of several lymphokines, especially IL-2. Shown to inhibit the activity of FK-506 binding protein, thereby reversing its effects on sarcoplasmic reticulum Ca+2 release.References Asano, K., et al.: In Vivo, 10, 537 (1996), McCall, E., et al.: Circ. Res., 79, 1110 (1996), Raufman, J.P., et al.: J. Biol. Chem., 271, 19877 (1996), Rokaw, M.D., et al.: Am. J. Physiol., 271, C194 (1996), Knoll, G.A., and Bell, R.C.: Brit. Med. J., 318, 1104 (1999)
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Chemical properties
Molecular weight:788.02
Formula:C44H69NO11
Color/Form:Neat
InChI:InChI=1S/C44H69NO11/c1-10-13-32-21-26(2)20-27(3)22-37(53-8)40-38(54-9)24-30(6)44(51,56-40)41(48)42(49)45-19-12-11-14-33(45)43(50)55-39(28(4)15-17-34(32)46)29(5)23-31-16-18-35(47)36(25-31)52-7/h10,21,23,27-28,30-33,35-40,47,51H,1,11-20,22,24-25H2,2-9H3/b26-21?,29-23+
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