DAPT

CAS: 208255-80-5

Ref. TR-D193290

Product Information

• Name: DAPT
• Synonyms: (2S)-N-[2-(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl-glycine 1,1-Dimethylethyl Ester, (2S)-N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl-glycine 1,1-Dimethylethyl Ester, DAPT (enzyme inhibitor), GSI-IX, N-[N-(3,5-Difluorophenacetyl)-L-alanyl]-S-phenylglycine tert-Butyl Ester N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-Butyl Ester ?-Secretase Inhibitor IX, An-37124, Dapt, Glycine, N-[(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-, Glycine, N-[2-(3,5-difluorophenyl)acetyl]-<span class="text-smallcaps">L</span>-alanyl-2-phenyl-, 1,1-dimethylethyl ester, (2S)-, Gsi-Ix, Ly-374973, N-[(3,5-Difluorophenyl)acetyl]-L-alanyl-2-phenyl]glycine-1,1-dimethylethyl ester, N-[N-(3,5-Difluorophenacetyl)-<span class="text-smallcaps">L</span>-alanyl]-S-phenylglycine tert-butyl ester, N-[N-(3,5-Difluorophenacetyl-L-alanyl)]-S-phenylglycine t-butyl ester, tert-butyl (2S)-({N-[(3,5-difluorophenyl)acetyl]-L-alanyl}amino)(phenyl)ethanoate, γ-Secretase inhibitor IX
• CAS: 208255-80-5

Description

Applications DAPT is a γ-secretase inhibitor which inhibits thegrowth of cancer cells and epethelial and mesenchymal transition (1,2).
References (1) Li, L. et al.: Oncol Lett. 7, 2160 (2014) (2) Wang, M. et al.: Int. J. Onc., 44, 1401 (2014)

• Brand: TRC

Chemical properties

• Molecular weight: 432.46
• Formula: C₂₃H₂₆F₂N₂O₄
• Color/Form: Off White Solid
• InChI: InChI=1S/C11H19NO7/c13-7-4-19-11(18,9(15)8(7)14)5-12-3-1-2-6(12)10(16)17/h6-9,13-15,18H,1-5H2,(H,16,17)/t6-,7-,8?,9?,11+/m0/s1
• InChI key: InChIKey=WDZMFMTVJVHSKA-ZJTSKWAESA-N
• SMILES: O=C(O)[C@@H]1CCCN1C[C@@]1(O)OC[C@H](O)C(O)C1O