Darinaparsin

CAS: 69819-86-9

Ref. TR-D193425

Product Information

• Name: Darinaparsin
• Synonyms: N-[S-(Dimethylarsino)-N-L-?-glutamyl-L-cysteinyl]-glycine, Dimethylarsinic Glutathione, ZIO 101, Zinapar, L-?-Glutamyl-S-(dimethylarsino)-L-cysteinyl-glycine, <span class="text-smallcaps">L</smallcap>-γ-Glutamyl-S-(dimethylarsino)-<smallcap>L</span>-cysteinylglycine, DMS(III)G，SGLU1，ZIO-101，Zinapar, Dimethylarsinic glutathione, Glycine, <span class="text-smallcaps">L</smallcap>-γ-glutamyl-S-(dimethylarsino)-<smallcap>L</span>-cysteinyl-, Glycine, N-[S-(dimethylarsino)-N-<span class="text-smallcaps">L</smallcap>-γ-glutamyl-<smallcap>L</span>-cysteinyl]-, Zio 101, Glycine, N-[S-(dimethylarsino)-N-L-γ-glutamyl-L-cysteinyl]-, Glycine, L-γ-glutamyl-S-(dimethylarsino)-L-cysteinyl-, L-γ-Glutamyl-S-(dimethylarsino)-L-cysteinylglycine

Description

Applications Darinaparsin is an arsenic cytotoxin that has been used in pharmacological activities to evaluate the effect on survival an radiosensitivity of tumor cells in vitro under normoxia and hypoxia and in vivo using xenograft models. Darinaparsin has significant and preferential cytotoxic and radiosensitizing effects on solid tumors as compared with normal cells. Darinaparsin may therefore increase the therapeutic index of radiation therapy and has near term translational potential.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Tian, J., et al.: Clin. Cancer Res., 18, 3366 (2012); Ning, S., et al.: Int. J. Radiat. Oncol. Biol. Phys., 65, 493 (2006);

• Brand: TRC

Chemical properties

• Molecular weight: 411.31
• Formula: C₁₂H₂₂AsN₃O₆S
• Color/Form: Neat
• InChI: InChI=1S/C21H34O3/c1-2-3-4-5-6-7-8-9-10-11-12-13-14-15-16-17-21(22)24-19-20-18-23-20/h3-4,6-7,9-10,20H,2,5,8,11-19H2,1H3/b4-3-,7-6-,10-9-
• InChI key: InChIKey=SGFJJNBUMXQSMU-PDBXOOCHSA-N
• SMILES: CC/C=C\C/C=C\C/C=C\CCCCCCCC(=O)OCC1CO1