Defluoro Flunarizine Dihydrochloride

CAS: 27064-96-6

Ref. TR-D228700

Product Information

• Name: Defluoro Flunarizine Dihydrochloride
• Synonyms: Piperazine, 1-[(4-fluorophenyl)phenylmethyl]-4-(3-phenyl-2-propen-1-yl)-, hydrochloride (1:2), Piperazine, 1-[(4-fluorophenyl)phenylmethyl]-4-(3-phenyl-2-propenyl)-, dihydrochloride (9CI), Piperazine, 1-cinnamyl-4-(p-fluoro-α-phenylbenzyl)-, dihydrochloride (8CI), 1-[(RS)-(4-Fluorophenyl)phenylmethyl]-4-[(2EZ)-3-phenylprop-2-enyl]piperazine dihydrochloride, (EZ)-Defluoro-flunarizine dihydrochloride
• Brand: TRC
• Description: Impurity Flumazenil EP Impurity BStability HygroscopicApplications Defluoro Flunarizine (Flumazenil EP Impurity B) Dihydrochloride, is an impurity of Flunarizine(F455200, Dihydrochloride), which is a calcium channel blocker. Flunarizine is a fluorinated derivative of Cinnarizine and a vasodilator (cerebral and peripheral).References Desmedt, L.K., et al.: Arzneim.-Forsch., 25, 1408 (1975), Godfraind, T., et al.: Eur. J. Pharmacol., 53, 273 (1979), Nihard, P., et al.: Angiology, 33, 37 (1982), Holmes, B., et al.: Drugs, 27, 6 (1984)

Chemical properties

• Molecular weight: 459.43
• Formula: C₂₆H₂₇FN₂·2ClH
• Color/Form: Neat
• InChI: InChI=1S/C26H27FN2.2ClH/c27-25-15-13-24(14-16-25)26(23-11-5-2-6-12-23)29-20-18-28(19-21-29)17-7-10-22-8-3-1-4-9-22;;/h1-16,26H,17-21H2;2*1H
• InChI key: InChIKey=GGYPVQFLPDMNDG-JXMROGBWSA-N
• SMILES: Fc1ccc(C(c2ccccc2)N2CCN(C/C=C/c3ccccc3)CC2)cc1