4,5-Dehydro(pyrimidin-2(1H)-one) Lopinavir

Ref. TR-D230125

Product Information

• Name: 4,5-Dehydro(pyrimidin-2(1H)-one) Lopinavir
• Synonyms: (S)-N-((2S,4S,5S)-5-(2-(2,6-Dimethylphenoxy)acetamido)-4-hydroxy-1,6-diphenylhexan-2-yl)-3-methyl-2-(2-oxo-2,3-dihydropyrimidin-1(6H)-yl)butanamide, Lopinavir Impurity
• Brand: TRC
• Description: Impurity Lopinavir ImpurityApplications 4,5-Dehydro(pyrimidin-2(1H)-one) Lopinavir is an impurity of Lopinavir (L469480); a selective HIV protease inhibitor and antiviral. It is a COVID19-related research product.References Sham, H.L., et al.: Antimicrob. Ag. Chemother., 42, 3218 (1998); Kumar, G.N., et al.: Drug Metab. Dispos., 27, 86 (1999); Murphy, R.L., et al.: Antiviral Ther., 4, Suppl. 3, 85 (1999)

Chemical properties

• Molecular weight: 626.78
• Formula: C₃₇H₄₆N₄O₅
• Color/Form: Neat
• InChI: InChI=1S/C37H46N4O5/c1-25(2)34(41-20-12-19-38-37(41)45)36(44)39-30(21-28-15-7-5-8-16-28)23-32(42)31(22-29-17-9-6-10-18-29)40-33(43)24-46-35-26(3)13-11-14-27(35)4/h5-19,25,30-32,34,42H,20-24H2,1-4H3,(H,38,45)(H,39,44)(H,40,43)/t30-,31-,32-,34?/m0/s1
• InChI key: InChIKey=OOFJDBYPWSKJAH-QZKHDZGUSA-N
• SMILES: Cc1cccc(C)c1OCC(=O)N[C@@H](Cc1ccccc1)[C@@H](O)C[C@H](Cc1ccccc1)NC(=O)C(C(C)C)N1CC=CNC1=O