5-Dehydro Tolvaptan-d7

CAS: 1296212-29-7

Ref. TR-D230352

Product Information

• Name: 5-Dehydro Tolvaptan-d7
• Synonyms: N-[4-[(7-Chloro-2,3,4,5-tetrahydro-5-oxo-1H-1-benzazepin-1-yl)carbonyl]-3-methylphenyl]-2-methylbenzamide-d7, 1H-1-Benzazepine, Benzamide Deriv.-d7, 7-Chloro-1-[2-methyl-4-[(2-methylbenzoyl)amino]benzoyl]-5-Oxo-2,3,4,5-tetrahydro-1H-1-benzazepine-d7

Description

Applications 5-Dehydro Tolvaptan-d7 is an intermediate in synthesizing Tolvaptan-d7 (T536652), a labelled Tolvaptan. It is a selective, competitive arginine vasopressin V2 receptor antagonist used to treat hyponatremia (low blood sodium levels) associated with congestive heart failure, cirrhosis, and the syndrome of inappropriate antidiuretic hormone (SIADH).
References Paterna, S., et al.: Eur. J. Heart Fail, 2, 305 (2000); Udelson, J., et al.: Circulation, 104, 2417 (2001); Goldsmith, S., et al.: J. Am. Coll Cardiol., 46, 1785 (2005); Schrier, R., et al.: N. Engl. J. Med., 355, 2099 (2006)

• Brand: TRC

Chemical properties

• Molecular weight: 453.97
• Formula: C₂₆H₁₆D₇ClN₂O₃
• Color/Form: Neat
• InChI: InChI=1S/C26H23ClN2O3/c1-16-6-3-4-7-20(16)25(31)28-19-10-11-21(17(2)14-19)26(32)29-13-5-8-24(30)22-15-18(27)9-12-23(22)29/h3-4,6-7,9-12,14-15H,5,8,13H2,1-2H3,(H,28,31)/i1D3,3D,4D,6D,7D
• InChI key: InChIKey=VENGMROMZOKURN-FFQSSJIFSA-N
• SMILES: [2H]c1c([2H])c([2H])c(C([2H])([2H])[2H])c(C(=O)Nc2ccc(C(=O)N3CCCC(=O)c4cc(Cl)ccc43)c(C)c2)c1[2H]