Demecolcine

CAS: 477-30-5

Ref. TR-D230785

Product Information

• Name: Demecolcine
• Synonyms: Colcemid, Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-, Colchamine, Colchicine, N-deacetyl-N-methyl-, Colchicine, N-deacetyl-N-methyl-, (-)-, (-)-Colchamine, Alkaloid H 3, from Colchicum antumnale, C 12669, Ciba 12669A, Colchamin, Deacetyl-N-methylcolchicine, Deacetylmethylcolchicine, Demecolcin, Desacetylmethylcolchicine, Desmecolcine, Kolchamin, N-Deacetyl-N-methylcolchicine, N-Desacetyl-N-methylcolchicine, N-Methyl-N-deacetylcolchicine, N-Methyl-N-desacetylcolchicine, N-Methyltri-O-methylcolchicinic acid, NSC 3096, Omain, Omaine, Reichstein's F, Santavy's substance F, Substance F, (7S)-1,2,3,10-Tetramethoxy-7-(methylamino)-6,7-dihydro-5H-benzo[a]heptalen-9-one, (7S)-1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one, (7S)-6,7-Dihydro-1,2,3,10-tetramethoxy-7-(methylamino)benzo[a]heptalen-9(5H)-one, (N-Desacetyl-N-methylcolchicine), 1,2,3,10-tetramethoxy-7-(methylamino)-6,7-dihydrobenzo[a]heptalen-9(5H)-one, Alkaloid H 3, from Colchicum antumnale, Alkaloid H 3, from Colchicumantumnale, Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (7S)-, Benzo[a]heptalen-9(5H)-one, 6,7-dihydro-1,2,3,10-tetramethoxy-7-(methylamino)-, (S)-, Colcemide, Colchicine, N-deacetyl-N-methyl-, Demecolcina, Demecolcine, (S)-(-)-, Nsc 3096
• CAS: 477-30-5

Description

Stability Hygroscopic
Applications An antimitotic agent that disrupts microtubles by binding to tubulin and preventing its polymerization. Stimulates the intrinsic GTPase activity of tubulin. Induces apoptosis in several normal and tumor cell lines and activates the JNK/SAPK signaling pathway.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Lunduena, R.F., et al.: Curr. Opin. Cell Biol., 4, 53 (1992), Ceccatelli, S., et al.: Neuroreport, 8, 3779 (1997), Want, T.H., et al.: J. Biol. Chem., 273, 4928 (1998), Andreu, J.M., et al.: Biochemistry, 37, 8356 (1998), Jordan, A., et al.: Med. Res. Rev., 18, 259 (1998),

• Brand: TRC

Chemical properties

• Molecular weight: 371.43
• Formula: C₂₁H₂₅NO₅
• Color/Form: Light Yellow to Very Dark Yellow Solid
• InChI: InChI=1S/C21H25NO5/c1-22-15-8-6-12-10-18(25-3)20(26-4)21(27-5)19(12)13-7-9-17(24-2)16(23)11-14(13)15/h7,9-11,15,22H,6,8H2,1-5H3/t15-/m0/s1
• InChI key: InChIKey=NNJPGOLRFBJNIW-HNNXBMFYSA-N
• SMILES: CN[C@H]1CCc2cc(OC)c(OC)c(OC)c2-c2ccc(OC)c(=O)cc21