3-Demethyl Thiocolchicine

CAS: 87424-25-7

Ref. TR-D231330

Product Information

• Name: 3-Demethyl Thiocolchicine
• Synonyms: Acetamide, N-[(7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-, Acetamide, N-[5,6,7,9-tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-, (S)-, Colchicine, 2-demethylthio- (6CI), Benzo[a]heptalene, acetamide deriv., N-[(7S)-5,6,7,9-Tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]acetamide, 3-Demethylthiocolchicine, 3-Desmethylthiocolchicine, 3-O-Demethylthiocolchicine, NSC 361792, Thiocolchicoside Impurity B, Acetamide, N-[(7S)-5,6,7,9-tetrahydro-3-hydroxy-1,2-dimethoxy-10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-, Acetamide, N-[5,6,7,9-tetrahydro-3-hydroxy-1,2-dimethoxy- 10-(methylthio)-9-oxobenzo[a]heptalen-7-yl]-, (S)-, Benzo[a]heptalene, acetamide deriv., Colchicine, 2-demethylthio-

Description

Stability Hygroscopic
Applications A Thiocolchicine metabolite, used in therapy as an antitunor, antiinflammatory and immunosuppressive agent.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Trellu, M., et al.: Fund. Clin. Pharmacol., 18, 493 (2004), Nakagawa-Goto, K., et al.: Bioorg. Med. Chem. Lett., 15, 235 (2005), Gelmi, M., et al.: J. Med. Chem., 50, 2245 (2007),

• Brand: TRC

Chemical properties

• Molecular weight: 401.48
• Formula: C₂₁H₂₃NO₅S
• Color/Form: Neat
• InChI: InChI=1S/C21H23NO5S/c1-11(23)22-15-7-5-12-9-17(25)20(26-2)21(27-3)19(12)13-6-8-18(28-4)16(24)10-14(13)15/h6,8-10,15,25H,5,7H2,1-4H3,(H,22,23)/t15-/m0/s1
• InChI key: InChIKey=PKYOHQGXPPVIGD-HNNXBMFYSA-N
• SMILES: COc1c(O)cc2c(c1OC)-c1ccc(SC)c(=O)cc1[C@@H](NC(C)=O)CC2