O-Demethoxypropane Aliskiren-d6

CAS: 949925-77-3

Ref. TR-D231417

Product Information

• Name: O-Demethoxypropane Aliskiren-d6
• Synonyms: (aS,?S,dS,?S)-d-Amino-N-(3-amino-2,2-dimethyl-3-oxopropyl)-?,3-dihydroxy-4-methoxy-a,?-bis(1-methylethyl)-d6-benzeneoctanamide, (2S,4S,5S,7S)-5-Amino-N-(3-amino-2,2-dimethyl-d6-3-oxopropyl)-4-hydroxy-7-(3-hydroxy-4-methoxybenzyl)-2-isopropyl-8-methylnonanamide

Description

Applications O-Demethoxypropane Aliskiren-d6 is the labeled analog of O-Demethoxypropane Aliskiren is an impurity of Aliskiren Hemifumarate (A536001), an orally active, synthetic nonpeptide renin inhibitor. Antihypertensive.
References Kumar, N.U., et. al.: Chem. Biol. Interface, 3, 304 (2013); Lefevre, G., et al.: J. Immunoassay, 21, 65 (2000); Allikments, K., et al.: Curr. Opin. Invest. Drugs, 3, 1479 (2002); Wood, J.M., et al.: Biochem. Biophys. Res. Commun., 308, 698 (2003); Grandman, A.H., et al.: Circulation, 111, 1012 (2005)

• Brand: TRC

Chemical properties

• Molecular weight: 485.7
• Formula: C₂₆H₃₉D₆N₃O₅
• Color/Form: Neat
• InChI: InChI=1S/C26H45N3O5/c1-15(2)18(10-17-8-9-23(34-7)22(31)11-17)12-20(27)21(30)13-19(16(3)4)24(32)29-14-26(5,6)25(28)33/h8-9,11,15-16,18-21,30-31H,10,12-14,27H2,1-7H3,(H2,28,33)(H,29,32)/t18-,19-,20-,21-/m0/s1/i5D3,6D3
• InChI key: InChIKey=LLUFOXYJKAAINV-BQYQJAHWSA-N
• SMILES: CON(C)/C=C/C(=O)COc1ccc(F)cc1