5'-Deoxy-5'-chloroadenosine

CAS: 892-48-8

Ref. TR-D232545

Product Information

• Name: 5'-Deoxy-5'-chloroadenosine
• Synonyms: 5'-Chloro-5'-deoxyadenosine, 5'-Chloro-5'-Deoxyadenosine, 5'-Chloro-5'-deoxyadenosin, 5′-Deoxy-5′-chloroadenosine, 9H-purin-6-amine, 9-(5-chloro-5-deoxypentofuranosyl)-, Adenosine, 5'-Chloro-5'-Deoxy-

Description

Applications 5'-Deoxy-5'-chloroadenosine is an intermediate in the synthesis of 5'-Deoxy-5'-(methylthio)adenosine (D242600), a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways.
References Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

• Brand: TRC

Chemical properties

• Molecular weight: 285.687
• Formula: C₁₀H₁₂ClN₅O₃
• Color/Form: Neat
• InChI: InChI=1S/C10H12ClN5O3/c11-1-4-6(17)7(18)10(19-4)16-3-15-5-8(12)13-2-14-9(5)16/h2-4,6-7,10,17-18H,1H2,(H2,12,13,14)/t4-,6-,7-,10-/m1/s1
• InChI key: InChIKey=IYSNPOMTKFZDHZ-KQYNXXCUSA-N
• SMILES: Nc1ncnc2c1ncn2[C@@H]1O[C@H](CCl)[C@@H](O)[C@H]1O