5'-Deoxy-5'-(methylthio)adenosine

CAS: 2457-80-9

Ref. TR-D242600

Product Information

• Name: 5'-Deoxy-5'-(methylthio)adenosine
• Synonyms: 5'-S-Methyl-5'-thioadenosine, 5'-(Methylthio)-5'-deoxyadenosine, 5'-(Methylthio)adenosine, 5'-Deoxy(methylthio)adenosine, 5'-S-Methylthioadenosine, NSC 335422, Vitamin L2, ß-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-, 5'-Deoxy-5'-Methylthioadenosine, 5'-Methylthioadenosine, 5′-(Methylthio)-5′-deoxyadenosine, 5′-Deoxy(methylthio)adenosine, 9-(5-S-methyl-5-thiopentofuranosyl)-9H-purin-6-amine, Adenosine, 5'-S-methyl-5'-thio-, Brn 0042420, Methylthioadenosine, Nsc 335422, Vitamin L(sub 2), Vitamin L₂, β-<span class="text-smallcaps">D</span>-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-

Description

Applications 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
References Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

• Brand: TRC

Chemical properties

• Molecular weight: 297.33
• Formula: C₁₁H₁₅N₅O₃S
• Color/Form: White To Off-White
• InChI: InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m1/s1