5'-Deoxy-5'-(methylthio)adenosine-d3

CAS: 2457-80-9

Ref. TR-D242602

Product Information

• Name: 5'-Deoxy-5'-(methylthio)adenosine-d3
• Synonyms: 5'-S-(Methyl-d3)-5'-thioadenosine, 5'-(Methylthio-d3)-5'-deoxyadenosine, 5'-(Methylthio-d3)adenosine, 5'-Deoxy(methylthio-d3)adenosine, 5'-S-(Methyl-d3)-5'-thioadenosine, 5'-S-(Methyl-d3)thioadenosine, NSC 335422-d3, Vitamin L2-d3, 1-(6-Amino-9H-purin-9-yl)-1-deoxy-5-S-(methyl-d3)-5-thio-ß-D-, 5'-(Methylthio)adenosine, 5'-Deoxy-5'-Methylthioadenosine, 5'-Methylthioadenosine, 5'-S-Methyl-5'-thioadenosine, 5'-S-Methylthioadenosine, 5′-(Methylthio)-5′-deoxyadenosine, 5′-Deoxy(methylthio)adenosine, 9-(5-S-methyl-5-thiopentofuranosyl)-9H-purin-6-amine, Adenosine, 5'-S-methyl-5'-thio-, Brn 0042420, Methylthioadenosine, Nsc 335422, Vitamin L(sub 2), Vitamin L2, Vitamin L₂, β-<span class="text-smallcaps">D</span>-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-, 4-26-00-03675 (Beilstein Handbook Reference), β-D-Ribofuranose, 1-(6-amino-9H-purin-9-yl)-1-deoxy-5-S-methyl-5-thio-

Description

Applications Labelled 5'-Deoxy-5'-(methylthio)adenosine (D242600). 5′-Deoxy-5′-(methylthio)adenosine (Methylthioadenosine) may be used as a substrate to study the specificity and kinetics of 5′-methylthioadenosinephosphorylase (MTAP) (EC2.4.2.28), a tumor suppressor gene expressed enzyme that supports the S-adenosylmethionine (AdoMet) and methionine salvage pathways. Methylthioadenosine is used in studies on bacterial quorum sensing pathways that envolve enzymes such as 5′-Methylthioadenosine/S-adenosylhomocysteine nucleosidase (MTAN).
References Pegg, A., et al.: Biochem. J., 115, 241 (1969), Olopade, O., et al.: Cancer Res., 53, 2410 (1993), Hartmann, S., et al.: Clin. Chem., 52, 1127 (2006), Penner, N., et al.: J. Pharm. Biomed. Anal., 52, 534 (2010),

• Brand: TRC

Chemical properties

• Molecular weight: 300.35
• Formula: C₁₁H₁₂D₃N₅O₃S
• Color/Form: Neat
• InChI: InChI=1S/C11H15N5O3S/c1-20-2-5-7(17)8(18)11(19-5)16-4-15-6-9(12)13-3-14-10(6)16/h3-5,7-8,11,17-18H,2H2,1H3,(H2,12,13,14)/t5-,7-,8-,11-/m0/s1/i1D3
• InChI key: InChIKey=WUUGFSXJNOTRMR-QIRPUESMSA-N
• SMILES: [2H]C([2H])([2H])SC[C@@H]1O[C@H](n2cnc3c(N)ncnc32)[C@@H](O)[C@H]1O