Desfluoromethyl Fluticasone Propionate Disulfide

CAS: 201812-64-8

Ref. TR-D289890

Product Information

• Name: Desfluoromethyl Fluticasone Propionate Disulfide
• Synonyms: Androsta-1,4-dien-3-one, 17,17'-(dithiodicarbonyl)bis[6,9-difluoro-11-hydroxy-16-methyl-17-(1-oxopropoxy)-, (6α,11β,16α,17α)-(6'α,11'β,16'α,17'α)-, 17,17′-(disulfanediyldicarbonyl)bis(6α,9-difluoro-11β-hydroxy-16α-methyl-3-oxoandrosta-1,4-dien-17α-yl) dipropanoate, Fluticasone Propionate Imp. H (EP), unidentified impurity with RRT 1.23, fluticasone dipropionate disulphide (GR 68620X), disulphide dipropionate dithioketone (GR 247095X), dithio (GR 269949X)
• Brand: TRC
• Description: Impurity Fluticasone EP Impurity HApplications Desfluoromethyl Fluticasone Propionate Disulfide is the disulfide conjugated dimer of Fluticasone Propionate (F599500), a derivative of flumethasone and an anti-inflammatory agent.References Mistry, N., et al.: J. Pharma. Biomed. Anal., 19, 511 (1999); Dalvi, P., et al.: J. Chem., 20, 187 (2008)

Chemical properties

• Molecular weight: 935.09
• Formula: C₄₈H₅₈F₄O₁₀S₂
• Color/Form: Off-White To Light Yellow
• InChI: InChI=1S/C48H58F4O10S2/c1-9-37(57)61-47(23(3)15-27-29-19-33(49)31-17-25(53)11-13-41(31,5)45(29,51)35(55)21-43(27,47)7)39(59)63-64-40(60)48(62-38(58)10-2)24(4)16-28-30-20-34(50)32-18-26(54)12-14-42(32,6)46(30,52)36(56)22-44(28,48)8/h11-14,17-18,23-24,27-30,33-36,55-56H,9-10,15-16,19-22H2,1-8H3/t23-,24-,27+,28+,29+,30+,33+,34+,35+,36+,41+,42+,43+,44+,45+,46+,47+,48+/m1/s1
• InChI key: InChIKey=OQDFECAXWAAOEZ-SKHUXIGSSA-N
• SMILES: CCC(=O)OC1(C(=O)SSC(=O)C2(OC(=O)CC)[C@H](C)C[C@H]3[C@@H]4C[C@H](F)C5=CC(=O)C=C[C@]5(C)[C@@]4(F)[C@@H](O)C[C@@]32C)[C@H](C)C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@@]21C