Desloratadine

CAS: 100643-71-8

Ref. TR-D290250

Product Information

• Name: Desloratadine
• Synonyms: Descarboethoxyloratadine,8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Aerius, Allex, Azomyr, Clarinex, NSC 675447, Neoclarityn, Opulis, Sch 34117, USP Loratadine Related Compound A, 8-Chloro-11-(4-piperidylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Delopedil, Descarboethoxyloratidine, Desler, Eurodesa, Sedno, 8-Chloro-6,11-dihydro-11-(4-piperidinylidene)-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Aerius, Allex, Azomyr, Clarinex, Descarboethoxyloratadine, Neoclarityn, Opulis, Sch 34117, USP Loratadine Related Compound A, Loratadine EP Impurity D, Loratadine USP Related Compound A, Loratadine Related Compound A, Loratadine Impurity D, Rupatadine Fumarate Impurity B, 5H-Benzo[5,6]cyclohepta[1,2-b]pyridine, 8-chloro-6,11-dihydro-11-(4-piperidinylidene)-, 8-chloro-11-(piperidin-4-ylidene)-6,11-dihydro-5H-benzo[5,6]cyclohepta[1,2-b]pyridine, Dasselta

Description

Impurity Loratadine EP Impurity D; Loratadine USP Related Compound A
Applications Desloratadine (Loratadine EP Impurity D; Loratadine USP Related Compound A) is an active metabolite of Loratadine (L469575) and used as an oral non-sedating antihistamine to relieve symptoms of allergic rhinitis and chronic idiopathic urticaria (1,2,3).
References (1) Bloom, M., et al.: Curr Med Res Opin. 20, 1959 (2004) (2) Kreutner, W., et al.: Arzneimittel-Forsch., 50, 345 (2000) (3) Salmun, L.M., et al.: Clin. Ther., 22, 613 (2000)

• Brand: TRC

Chemical properties

• Molecular weight: 310.82
• Formula: C₁₉H₁₉ClN₂
• Color/Form: White Solid
• InChI: InChI=1S/C19H19ClN2/c20-16-5-6-17-15(12-16)4-3-14-2-1-9-22-19(14)18(17)13-7-10-21-11-8-13/h1-2,5-6,9,12,21H,3-4,7-8,10-11H2
• InChI key: InChIKey=JAUOIFJMECXRGI-UHFFFAOYSA-N
• SMILES: Clc1ccc2c(c1)CCc1cccnc1C2=C1CCNCC1