3-Des(2-methoxyethyl) 3-(1-Methylethyl) Ester Nimodipine

CAS: 21881-78-7

Ref. TR-D291310

Product Information

• Name: 3-Des(2-methoxyethyl) 3-(1-Methylethyl) Ester Nimodipine
• Synonyms: Bis(1-methylethyl) 2,6-Dimethyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, Nimodipine Imp. B (EP), Nimodipine Impurity B, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, bis(1-methylethyl) ester, 3,5-Bis(1-methylethyl) 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-3,5-pyridinedicarboxylate, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(m-nitrophenyl)-, diisopropyl ester, 3,5-Pyridinedicarboxylic acid, 1,4-dihydro-2,6-dimethyl-4-(3-nitrophenyl)-, 3,5-bis(1-methylethyl) ester, 2,6-Dimethyl-4-(3-nitro-phenyl)-1,4-dihydro-pyridine-3,5-dicarboxylic acid diisopropyl ester

Description

Impurity Nimodipine EP Impurity B
Applications 3-Des(2-methoxyethyl) 3-(1-Methylethyl) Ester Nimodipine (Nimodipine EP Impurity B) can be used in synthetic preparation of dihydropyridinedicarboxylic acid esters by methylimidazolium trifluoroacetate-catalyzed Hantzsch cyclocondensation reaction of oxo-carboxylic acid esters with aldehydes and ammonium acetate. It can also be used as an analyte for analytical study in developing and optimizing a validated isocratic reversed-phase high-performance liquid chromatograhy separation of nimodipine and impurities in tablets using experimental. design methodology. It is an impurity of the drug Nimodipine (N478200).
References Avalani, J. R., et al.: J. Chem. Sci., 124, 1091-1096 (2012); Barmpalexis, P., et al.: J. Pharmaceut. Biomed., 49, 1192-1202 (2009)

• Brand: TRC

Chemical properties

• Molecular weight: 402.44
• Formula: C₂₁H₂₆N₂O₆
• Color/Form: Neat
• InChI: InChI=1S/C21H26N2O6/c1-11(2)28-20(24)17-13(5)22-14(6)18(21(25)29-12(3)4)19(17)15-8-7-9-16(10-15)23(26)27/h7-12,19,22H,1-6H3
• SMILES: CC1=C(C(=O)OC(C)C)C(c2cccc([N+](=O)[O-])c2)C(C(=O)OC(C)C)=C(C)N1