Product Information
Name:O-Desmethyl Midostaurin-d5
Controlled Product
Synonyms:
- 2,3,4,5,6-pentadeuterio-N-[(2S,3R,4R,6R)-3-hydroxy-2-methyl-16-oxo-29-oxa-1,7,17-triazaoctacyclo[12.12.2.12,6.07,28.08,13.015,19.020,27.021,26]nonacosa-8(13),9,11,14(28),15(19),20(27),21(26),22,24-nonaen-4-yl]-N-methylbenzamide
Brand:TRC
Description:Applications O-Desmethyl Midostaurin-d5 is a deuterium labelled derivative of O-Desmethyl Midostaurin (D291400(M)). O-Desmethyl Midostaurin is a metabolite of Midostaurin (M343760), a compound shown to possess antiproliferative characteristics via inhibition of protein kinase C, kinase insert domain receptor, and c-kit. O-Desmethyl Midostaurini is also an active metabolite involved in cytochrome P450 liver enzyme metabolism.References Tahtouh, T., et al.: J. Med. Chem., 55, 9312 (2012); Pedeboscq, S., et al.: PLoS. One., 7, 36811 (2012); Levis, M., et al.: NLM, 108, 3477 (2006)
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Chemical properties
Molecular weight:561.641
Formula:C34D5H23N4O4
Color/Form:Neat
InChI:InChI=1S/C34H28N4O4/c1-34-31(39)24(36(2)33(41)18-10-4-3-5-11-18)16-25(42-34)37-22-14-8-6-12-19(22)27-28-21(17-35-32(28)40)26-20-13-7-9-15-23(20)38(34)30(26)29(27)37/h3-15,24-25,31,39H,16-17H2,1-2H3,(H,35,40)/t24-,25-,31-,34+/m1/s1/i3D,4D,5D,10D,11D
InChI key:InChIKey=PXOCRDZEEXVZQC-CANNTNAISA-N
SMILES:[2H]c1c([2H])c([2H])c(C(=O)N(C)[C@@H]2C[C@H]3O[C@@](C)([C@@H]2O)n2c4ccccc4c4c5c(c6c7ccccc7n3c6c42)C(=O)NC5)c([2H])c1[2H]
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