2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir

CAS: 1193687-85-2

Ref. TR-D293085

Product Information

• Name: 2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir
• Synonyms: 2-[1-[[(Dimethylamino)methylene]amino]-1-methylethyl]-N-[(4-fluorophenyl)methyl]-1,6-dihydro-5-hydroxy-1-methyl-6-oxo-4-pyrimidinecarboxamide

Description

Applications 2-Des(5-methyl-1,3,4-oxadiazole-2-carboxamide) (E)-2-(N,N-Dimethylformimidamide) Raltegravir is an impurity of Raltegravir (R100300), a potent human immunodeficiency virus (HIV) integrase inhibitor. A novel anti-AIDS drug.
References Wade, K., et al.: J. Pharmacol. Biomed. Anal., 8, 401 (1990), Hazuda, D., et al.: Science, 287, 646 (2000), Williams, J., et al.: Drug Metab. Dispos., 32, 1201 (2004), Duckett, C., et al.: Xenobiotica, 36, 59 (2006), Miners, J., et al.: Biochem. Pharmacol., 71, 1531 (2006), Summa, V., et al.: J. Med. Chem., 49, 6646 (2006),

• Brand: TRC

Chemical properties

• Molecular weight: 389.42
• Formula: C₁₉H₂₄FN₅O₃
• Color/Form: Neat
• InChI: InChI=1S/C19H24FN5O3/c1-19(2,22-11-24(3)4)18-23-14(15(26)17(28)25(18)5)16(27)21-10-12-6-8-13(20)9-7-12/h6-9,11,26H,10H2,1-5H3,(H,21,27)/b22-11-
• InChI key: InChIKey=MEBOBLUKSXGASS-JJFYIABZSA-N
• SMILES: CN(C)/C=N\C(C)(C)c1nc(C(=O)NCc2ccc(F)cc2)c(O)c(=O)n1C