Desmethyl 7-Methoxycarbonyl Nintedanib (Nintedanib Impurity C)

Ref. TR-D293098

Product Information

• Name: Desmethyl 7-Methoxycarbonyl Nintedanib (Nintedanib Impurity C)
• Synonyms: methyl (3Z)-3-[[4-[[2-(4-methylpiperazin-1-yl)acetyl]amino]anilino]-phenylmethylidene]-2-oxo-1H-indole-7-carboxylate
• Brand: TRC
• Description: Applications Desmethyl 7-Methoxycarbonyl Nintedanib is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Chemical properties

• Molecular weight: 525.598
• Formula: C₃₀H₃₁N₅O₄
• Color/Form: Neat
• InChI: InChI=1S/C30H31N5O4/c1-34-15-17-35(18-16-34)19-25(36)31-21-11-13-22(14-12-21)32-27(20-7-4-3-5-8-20)26-23-9-6-10-24(30(38)39-2)28(23)33-29(26)37/h3-14,32H,15-19H2,1-2H3,(H,31,36)(H,33,37)/b27-26-
• InChI key: InChIKey=LGNSHPJXEOHMCG-RQZHXJHFSA-N
• SMILES: COC(=O)c1cccc2c1NC(=O)/C2=C(\Nc1ccc(NC(=O)CN2CCN(C)CC2)cc1)c1ccccc1