3-Desmethyl Trimethoprim

CAS: 27653-69-6

Ref. TR-D295705

Product Information

• Name: 3-Desmethyl Trimethoprim
• Synonyms: 5-[(2,4-Diamino-5-pyrimidinyl)methyl]-2,3-dimethoxy-phenol, a-(2,4-Diamino-5-pyrimidinyl)-5,6-dimethoxy-m-cresol, 2,4-Diamino-5-(3-hydroxy-4,5-dimethoxybenzyl)pyrimidine, 3-Demethyltrimethoprim, 3'-Hydroxytrimethoprim

Description

Applications 3-Desmethyl Trimethoprim is a metabolite of Trimethoprim (T795615); an antibacterial agent that is commonly prescribed in conjunction with Sulfametoxazole (S699086) to treat patients afflicted with urinary tract infections. 3-Desmethyl Trimethoprim gets excreted in the urine of rats, dogs, and man in the form of glucuronides.
References Roth, B., et al.: J. Med. Chem., 24, 933 (1981); Liu, Z., et al.: Biomed. Chromatogr., 26, 1101 (2012); Schwartz, D. E., Arzneimittel-Forsch., 20, 1867 (1970)

• Brand: TRC

Chemical properties

• Molecular weight: 276.29
• Formula: C₁₃H₁₆N₄O₃
• Color/Form: White To Light Brown
• InChI: InChI=1S/C13H16N4O3/c1-19-10-5-7(4-9(18)12(10)20-2)3-8-6-11(14)17-13(15)16-8/h4-6,18H,3H2,1-2H3,(H4,14,15,16,17)
• InChI key: InChIKey=LTSNBKHSOYWPEN-UHFFFAOYSA-N
• SMILES: COc1cc(Cc2cc(N)nc(N)n2)cc(O)c1OC