Dexamethasone Phosphate

CAS: 312-93-6

Ref. TR-D298835

Product Information

• Name: Dexamethasone Phosphate
• Synonyms: Pregna-1,4-diene-3,20-dione, 9-fluoro-11ß,17,21-trihydroxy-16a-methyl-, 21-(dihydrogen phosphate), Pregna-1,4-diene-3,20-dione, 9-fluoro-11ß,17,21-trihydroxy-16a-methyl-, 21-phosphate, Betnelan phosphate, Dexamethasone 21-dihydrogen phosphate, Dexamethasone 21-phosphate, Dexamethasone orthophosphate, Micromethason, Wymesone, (11β,16α)-9-Fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)pregna-1,4-diene-3,20-dione, Dexamethasone phosphate, Pregna-1,4-Diene-3,20-Dione, 9-Fluoro-11,17-Dihydroxy-16-Methyl-21-(Phosphonooxy)-, (11Beta,16Alpha)-, Pregna-1,4-diene-3,20-dione, 9-fluoro-11,17-dihydroxy-16-methyl-21-(phosphonooxy)-, (11β,16α)-, Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-(dihydrogen phosphate), Pregna-1,4-diene-3,20-dione, 9-fluoro-11β,17,21-trihydroxy-16α-methyl-, 21-phosphate, (11beta,16alpha)-9-Fluoro-11,17-dihydroxy-16-methyl-3,20-dioxopregna-1,4-dien-21-yl dihydrogen phosphate

Description

Applications A pro-drug of Dexamethasone (D298800), an anti-inflammatory glucocorticoid. It was found that liposomal DXM-P inhibited both chronic inflammation and joint destruction, whereas free DXM-P failed to prevent joint destruction.
References Kodelja, V., et al.: J. Immunol., 160, 1411 (1998), Metselaar, J., et al.: Arthritis Rheum., 48, 2059 (2003), Buttgereit, F., et al.: Arthritis Rheum., 50, 3408 (2004), Martinez, F., et al.: Front Biosci., 13, 453 (2008),

• Brand: TRC

Chemical properties

• Molecular weight: 472.44
• Formula: C₂₂H₃₀FO₈P
• Color/Form: White To Light Brown
• InChI: InChI=1S/C22H30FO8P/c1-12-8-16-15-5-4-13-9-14(24)6-7-19(13,2)21(15,23)17(25)10-20(16,3)22(12,27)18(26)11-31-32(28,29)30/h6-7,9,12,15-17,25,27H,4-5,8,10-11H2,1-3H3,(H2,28,29,30)/t12-,15+,16+,17+,19+,20+,21+,22+/m1/s1
• InChI key: InChIKey=VQODGRNSFPNSQE-CXSFZGCWSA-N
• SMILES: C[C@@H]1C[C@H]2[C@@H]3CCC4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@@]1(O)C(=O)COP(=O)(O)O