1-(Diaminomethylene)-3-b-D-ribofuranosyl-urea Picrate

CAS: 4336-46-3

Ref. TR-D417660

Product Information

• Name: 1-(Diaminomethylene)-3-b-D-ribofuranosyl-urea Picrate
• Synonyms: Azacitidine Related Compound C (USP),NSC 232826, 1-beta-D-Ribofuranosyl-3-guanylurea picrate, Urea, N-(aminoiminomethyl)-N'-beta-D-ribofuranosyl-, compd. with 2,4,6-trinitrophenol (1:1), Urea, 1-(diaminomethylene)-3-beta-D-ribofuranosyl-, picrate (7CI), Urea, 1-amidino-3-beta-D-ribofuranosyl-, monopicrate (8CI), Azacitidine RC C
• Brand: TRC
• Description: Impurity Azacitidine USP Related Compound CStability HygroscopicApplications 1-(Diaminomethylene)-3-β-D-ribofuranosyl-urea Picrate is a related compound of Azacitidine, a DNA metnyltransferase (DNMT) inhibitor for treating myelodysplastic syndromes (MDS).References Rajendiran, C., et al.: PCT Int. Appl. WO 2012135405 A1 20121004 (2012); Ziemba, A., et al.: Chemother Res Pract 965826, 9 (2011); Beisler, J. A., et al.: J. Carbohyd. Chem 4, 281 (1977)

Chemical properties

• Molecular weight: 463.31
• Formula: C₇H₁₄N₄O₅·C₆H₃N₃O₇
• Color/Form: Yellow
• InChI: InChI=1S/C7H14N4O5.C6H3N3O7/c8-6(9)11-7(15)10-5-4(14)3(13)2(1-12)16-5;10-6-4(8(13)14)1-3(7(11)12)2-5(6)9(15)16/h2-5,12-14H,1H2,(H5,8,9,10,11,15);1-2,10H/t2-,3-,4-,5-;/m1./s1
• SMILES: N=C(N)NC(=O)N[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O.O=[N+]([O-])c1cc([N+](=O)[O-])c(O)c([N+](=O)[O-])c1