Desmethyl Nintedanib Carboxylic Acid (Nintedanib Impurity A)

Ref. TR-D422368

Product Information

• Name: Desmethyl Nintedanib Carboxylic Acid (Nintedanib Impurity A)
• Brand: TRC
• Description: Applications Desmethyl Nintedanib Carboxylic Acid is an impurity of Intedanib (I666650), which is an indolinone derivative potently blocking VEGF-, PDGF-, and FGF-receptor kinases. it is an indolinone as triple angiokinase inhibitors and an antitumor agent.References Sun, L., et al.: J. Med. Chem., 41, 2588 (1998); Xie, H., et al.: J. Med. Chem., 50, 4898 (2007); Hilberg, F., et al.: Cancer Res., 68, 4774 (2008); Roth, G., et al.: J. Med. Chem., 58, 1053 (2015)

Chemical properties

• Molecular weight: 527.57
• Formula: C₂₉H₂₉N₅O₅
• Color/Form: Neat
• InChI: InChI=1S/C29H29N5O5/c1-33-13-15-34(16-14-33)18-25(35)30-21-8-10-22(11-9-21)31-27(19-5-3-2-4-6-19)26-23-12-7-20(29(37)39-38)17-24(23)32-28(26)36/h2-12,17,31,38H,13-16,18H2,1H3,(H,30,35)(H,32,36)/b27-26-
• InChI key: InChIKey=PRQXQLSNPWNJER-RQZHXJHFSA-N
• SMILES: CN1CCN(CC(=O)Nc2ccc(N/C(=C3\C(=O)Nc4cc(C(=O)O)ccc43)c3ccccc3)cc2)CC1