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4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile
CAS: 380843-81-2
Ref. TR-D435305
| 5mg | 173.00 € | ||
| 25mg | 627.00 € | ||
| 50mg | 1,144.00 € |
Product Information
- N-Desmethyl Bosutinib
Applications Proteolysis Targeting Chimera (PROTAC) is a novel approach to modern drug development programs that utilizes small compounds to target proteins for ubiquitination and degradation by proteasome. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile is a PROTAC compound, which has the potential to target oncogenic BCR-ABL for degradation. 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile has also been employed in ligand-based pharmacophore modelling to identify c-Src inhibitors.
References Lai, A. C., et al., Angew. Chem. Int. Ed. 55, 807 (2016); Sakkiah, S., et al., J. Enzyme Inhib. Med. Chem. 29, 69 (2014)
Chemical properties
Technical inquiry about: TR-D435305 4-[(2,4-Dichloro-5-methoxyphenyl)amino]-6-methoxy-7-[3-(1-piperazinyl)propoxy]-3-quinolinecarbonitrile
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