Diclofenamide

CAS: 120-97-8

Ref. TR-D436530

Product Information

• Name: Diclofenamide
• Synonyms: m-Benzenedisulfonamide, 4,5-dichloro-, 1,3-Disulfamoyl-4,5-dichlorobenzene, 1,3-Disulfamyl-4,5-dichlorobenzene, 3,4-Dichloro-5-sulfamylbenzenesulfonamide, 4,5-Dichloro-1,3-disulfamoylbenzene, 4,5-Dichloro-m-benzenedisulfonamide, Antidrasi, CB 8000, Daramide, Daranide, Dichlofenamide, Dichlorophenamide, Dichlorphenamide, Diclofenamid, Glaucol, Oratrol, 1, 2-Dichlorobenzene-3, 5-disulfoneamide, 1,3-Benzenedisulfonamide, 4,5-dichloro-, 4,5-Dichloro-1,3-benzenedisulfonamide, 4,5-Dichlorobenzene-1,3-Disulfonamide, 4,5-Dichlorobenzene-1,3-Disulphonamide, Cb 8000, Diclofenamida, Keveyis, m-Benzenedisulfonamide, 4,5-dichloro-

Description

Applications Diclofenamide is a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP).
References Brzozowski, Z. et al.: Eur. J. Med. Chem., 46, 3656 (2010); Tawil, R. et al.: Ann. Neurol., 47, 46 (2000); Casey, J. et al.: J. Med. Chem., 47, 2337 (2004);

• Brand: TRC

Chemical properties

• Molecular weight: 305.16
• Formula: C₆H₆Cl₂N₂O₄S₂
• Color/Form: Neat
• InChI: InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)
• InChI key: InChIKey=GJQPMPFPNINLKP-UHFFFAOYSA-N
• SMILES: NS(=O)(=O)c1cc(Cl)c(Cl)c(S(N)(=O)=O)c1