Diclofenamide-13C6

CAS: 1391054-76-4

Ref. TR-D436532

Product Information

• Name: Diclofenamide-13C6
• Synonyms: 1,3-Disulfamoyl-4,5-dichlorobenzene-13C6, 1,3-Disulfamyl-4,5-dichlorobenzene-13C6, 3,4-Dichloro-5-sulfamylbenzenesulfonamide-13C6, 4,5-Dichloro-1,3-disulfamoylbenzene-13C6, 4,5-Dichloro-m-benzenedisulfonamide-13C6, Antidrasi-13C6, CB 8000-13C6, Daramide-13C6, Daranide-13C6, Dichlofenamide-13C6, Dichlorophenamide-13C6, Dichlorphenamide-13C6, Diclofenamid-13C6, Glaucol-13C6, Oratrol-13C6

Description

Applications Labelled Diclofenamide, a potent carbonic anhydrase inhibitor. Diclofenamide may provide a therapeutic strategy in the inhibition of the human cytosolic isoforms I and II and transmembrane tumor-associated isoenzymes IX and XII. Diclofenamide has been shown to be is effective in the prevention of episodic weakness in both hypokalemic periodic paralysis (HypoPP) and potassium-sensitive periodic paralysis (PSPP).
References Brzozowski, Z. et al.: Eur. J. Med. Chem., 46, 3656 (2010); Tawil, R. et al.: Ann. Neurol., 47, 46 (2000); Casey, J. et al.: J. Med. Chem., 47, 2337 (2004);

• Brand: TRC

Chemical properties

• Molecular weight: 311.11
• Formula: C₆H₆Cl₂N₂O₄S₂
• Color/Form: Neat
• InChI: InChI=1S/C6H6Cl2N2O4S2/c7-4-1-3(15(9,11)12)2-5(6(4)8)16(10,13)14/h1-2H,(H2,9,11,12)(H2,10,13,14)/i1+1,2+1,3+1,4+1,5+1,6+1
• InChI key: InChIKey=GJQPMPFPNINLKP-IDEBNGHGSA-N
• SMILES: NS(=O)(=O)[13c]1[13cH][13c](Cl)[13c](Cl)[13c](S(N)(=O)=O)[13cH]1