N-Didesmethyl Loperamide-d4

CAS: 66164-06-5

Ref. TR-D441137

Product Information

• Name: N-Didesmethyl Loperamide-d4
• Synonyms: 4-(4-Chlorophenyl)-4-hydroxy-a,a-diphenyl-1-piperidinebutanamide-d4, 4-(4-(4-Chlorophenyl)-4-hydroxypiperidin-1-yl)-2,2-diphenylbutanamide-d4, R 21345-d4

Description

Applications N-Didesmethyl Loperamide-d4 is the isotope labelled analog of N-Didesmethyl Loperamide (D441135); a metabolite of the antidiarrheal Loperamide (L469450, HCl). Also a new and improved PET radiotracer for imaging P-gp function.
Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the package
References Stokbroekx, et al.: J. Med. Chem., 1, 782 (1973); Carter, J.E., et al.: Anal. Profiles Drug Subs., 19, 341 (1990); Rahman, A., et al.: Cancer Res., 54, 5543 (1994); Sai, Y., et al.: Xenobiotica, 30, 327 (2000); Eneroth, A., et al.: Eur. J. Pharm. Sci., 12, 205 (2001); Kim, K., et al.: Drug Metab. Dispos., 31, 1090 (2003)

• Brand: TRC

Chemical properties

• Molecular weight: 391.738
• Formula: C₂₇H₂₅D₄ClN₂O₂
• Color/Form: Neat
• InChI: InChI=1S/C27H29ClN2O2/c28-24-13-11-21(12-14-24)26(32)15-18-30(19-16-26)20-17-27(25(29)31,22-7-3-1-4-8-22)23-9-5-2-6-10-23/h1-14,32H,15-20H2,(H2,29,31)/i17D2,20D2
• InChI key: InChIKey=PSXOKXJMVRSARX-BYPYZUCNSA-N
• SMILES: O=S(=O)(N[C@@H](CO)C(C(F)(F)F)C(F)(F)F)c1ccc(Cl)s1