2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone

CAS: 86404-63-9

Ref. TR-D445885

Product Information

• Name: 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone
• Synonyms: Voriconazole Imp. A (EP), 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)ethanone,Ethanone, 1-(2,4-difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-, 1-(2,4-Difluorophenyl)-2-(1H-1,2,4-triazol-1-yl)-1-ethanone, 1-(2,4-Difluorophenyl)-2-(4H-1,3,4-triazol-4-yl)ethan-1-one, 2',4'-Difluoro-2-(1,2,4-triazol-1-yl)acetophenone, 2',4'-Difluoro-2-(1H-1,2,4-triazol-1-yl)acetophenone, UK 51060
• Brand: TRC
• Description: Impurity Voriconazole EP Impurity A; Voriconazole USP Related Compound CApplications 2,4-Difluoro-α-(1H-1,2,4-triazolyl)acetophenone (Voriconazole EP Impurity A; Voriconazole USP Related Compound C) is an antifungal activity, particularly toward Candida albicans and Candida parapsilosisReferences Upadhayaya, R., et al.: Eur. J. Med. Chem., 39, 579 (2004), Sheng, C., et al.: J. Med. Chem., 49, 2512 (2006),

Chemical properties

• Molecular weight: 223.18
• Formula: C₁₀H₇F₂N₃O
• Color/Form: Beige
• InChI: InChI=1S/C10H7F2N3O/c11-7-1-2-8(9(12)3-7)10(16)4-15-6-13-5-14-15/h1-3,5-6H,4H2
• InChI key: InChIKey=XCHRPVARHBCFMJ-UHFFFAOYSA-N
• SMILES: O=C(Cn1cncn1)c1ccc(F)cc1F