Diformyldapsone

CAS: 6784-25-4

Ref. TR-D445908

Product Information

• Name: Diformyldapsone
• Synonyms: 4,4'-Sulfonylbis-formanilide, 4',4''-Sulfonylbis-formanilide, 4',4'''-Sulfonylbis-formanilide, N,N'-(Sulfonyldi-4,1-phenylene)bis[formamide], 4,4'-Diformamidodiphenyl Sulfone, DFD, DFD (pharmaceutical), DFDDS, Diformyl Diaminodiphenylsulfone, Diformyl-4,4'-sulfonyldianiline, Diformyl-4,4'-sulfonyldianiline, Formilone, NSC 53674, p,p'-Sulfonylbis(formanilide), N,N′-(Sulfonyldi-4,1-phenylene)bis[formamide], Formanilide, 4,4′-sulfonylbis-, Formanilide, 4′,4′′-sulfonylbis-, Formamide, N,N′-(sulfonyldi-4,1-phenylene)bis-, Formanilide, 4′,4′′′-sulfonylbis-

Description

Applications Diformyldapsone is an effective treatment of murine and human P. carinii pneumonitis. Also, it is a derivative of the parent compound, Dapsone (D193250), which is an antibacterial used in the treatment of dermatitis herpetiformis.
References Hughes, W. T., et al.: Antimicrob. Agents Chemother., 29, 509-510 (1986); Francis, J., et al.: Br. J. Pharmacol., 5, 565 (1950), Uetrecht, J., et al.: Clin. Dermatol., 7, 111 (1989); Reszka, K., et al.: Chem. Res. Toxicol., 22, 1137 (2009), Santos, J., et al.: Bioorg. Med. Chem., 17, 3795 (2009), Varma, M., et al.: J. Med. Chem., 52, 4844 (2009)

• Brand: TRC

Chemical properties

• Molecular weight: 304.321
• Formula: C₁₄H₁₂N₂O₄S
• Color/Form: Neat
• InChI: InChI=1S/C14H12N2O4S/c17-9-15-11-1-5-13(6-2-11)21(19,20)14-7-3-12(4-8-14)16-10-18/h1-10H,(H,15,17)(H,16,18)
• InChI key: InChIKey=NOWADDNUCMOPLH-UHFFFAOYSA-N
• SMILES: O=CNc1ccc(S(=O)(=O)c2ccc(NC=O)cc2)cc1