(8Beta)-8-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-6-methylergoline

CAS: 955957-39-8

Ref. TR-D446895

Product Information

• Name: (8Beta)-8-[[[(1,1-Dimethylethyl)dimethylsilyl]oxy]methyl]-6-methylergoline
• Synonyms: [(6aR,9R,10aR)-7-methyl-6,6a,8,9,10,10a-hexahydro-4H-indolo[4,3-fg]quinoline-9-yl]methoxy-tert-butyl-dimethylsilane
• Brand: TRC

Description

Applications (8β)-8-[[[(1,1-dimethylethyl)dimethylsilyl]oxy]methyl]-6-methylergoline is an protected intermediate in the synthesis of cabergoline (C050000) which is a dopamine D2-receptor agonist.
References Gazak, R., et al.: Tetrahedron., 63, 10466 (2007);

Chemical properties

• Molecular weight: 370.6
• Formula: C₂₂H₃₄N₂OSi
• Color/Form: Neat
• InChI: InChI=1S/C22H34N2OSi/c1-22(2,3)26(5,6)25-14-15-10-18-17-8-7-9-19-21(17)16(12-23-19)11-20(18)24(4)13-15/h7-9,12,15,18,20,23H,10-11,13-14H2,1-6H3/t15-,18-,20-/m1/s1
• InChI key: InChIKey=WDGVVXRSGNUPRU-XFQXTVEOSA-N
• SMILES: CN1C[C@H](CO[Si](C)(C)C(C)(C)C)C[C@@H]2c3cccc4[nH]cc(c34)C[C@H]21