Dihydroberberine

CAS: 483-15-8

Ref. TR-D446915

Product Information

• Name: Dihydroberberine
• Synonyms: 6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8-dihydro-9,10-dimethoxy-, Berberine, dihydro- (6CI,7CI), Berbine, 13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)- (8CI), 7,8-Dihydroberberine, Dihydroumbellatine, NSC 331264, 5,8-Dihydro-9,10-dimethoxy-6H-benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 6H-1,3-benzodioxolo[5,6-a]benzo[g]quinolizine, 5,8-dihydro-9,10-dimethoxy-, 6H-Benzo[g]-1,3-benzodioxolo[5,6-a]quinolizine, 5,8-dihydro-9,10-dimethoxy-, 9,10-Dimethoxy-5,8-dihydro-6H-[1,3]dioxolo[4,5-g]isoquino[3,2-a]isoquinoline, Berberine, dihydro-, Berbine, 13,13a-didehydro-9,10-dimethoxy-2,3-(methylenedioxy)-

Description

Applications Dihydroberberine is a derivative Berberine (B318150), an isoqinoline alkaloid shown to have a chemopreventive property against colon tumor formation by inhibiting the enzyme cyclooxygenase-2 (cox-2) which is abundantly expressed in colon cancer cells.
References Zhang, X. et al.: Cancer Res., 70, 9895 (2010); Lin, H.L. et al.: Cancer 85, 1937(1999); Schumacher, M.A. et al.: Science, 294, 2158 (2001); Fukuda, K. et al.: J. Ethno., 66, 227(1999);

• Brand: TRC

Chemical properties

• Molecular weight: 337.369
• Formula: C₂₀H₁₉NO₄
• Color/Form: Neat
• InChI: InChI=1S/C20H19NO4/c1-22-17-4-3-12-7-16-14-9-19-18(24-11-25-19)8-13(14)5-6-21(16)10-15(12)20(17)23-2/h3-4,7-9H,5-6,10-11H2,1-2H3
• InChI key: InChIKey=FZAGOOYMTPGPGF-UHFFFAOYSA-N
• SMILES: COc1ccc2c(c1OC)CN1CCc3cc4c(cc3C1=C2)OCO4