Difluocortolone

CAS: 2607-06-9

Ref. TR-D447019

Product Information

• Name: Difluocortolone
• Synonyms: Diflucortolone, (6alpha,11beta,16alpha)-6,9-Difluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione, 6alpha,9-Difluoro-11beta,21-dihydroxy-16alpha-methylpregna-1,4-diene-3,20-dione, (6S,8S,9R,10S,11S,13S,14S,16R,17S)-6,9-Difluoro-11-hydroxy-17-(2-hydroxyacetyl)-10,13,16-trimethyl-6,7,8,9,10,11,12,13,14,15,16,17-dodecahydro-3H-cyclopenta[a]phenanthren-3-one,, (6Alpha,11Beta,16Alpha)-6,9-Difluoro-11,21-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione, (6Alpha,8Xi,10Xi,13Xi,14Xi,16Alpha,17Xi)-6,9-Difluoro-11,21-Dihydroxy-16-Methylpregna-1,4-Diene-3,20-Dione, (6α,11β,16α)-6,9-Difluoro-11,21-dihydroxy-16-methylpregna-1,4-diene-3,20-dione, 6α,9-Difluoro-11β,21-dihydroxy-16α-methylpregna-1,4-diene-3,20-dione, Diflucortolona, Diflucortolona [INN-Spanish], Diflucortolone [USAN:INN:BAN], Diflucortolonum, Diflucortolonum [INN-Latin], Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16-methyl-, (6alpha,11beta,16alpha)-, Pregna-1,4-diene-3,20-dione, 6,9-difluoro-11,21-dihydroxy-16-methyl-, (6α,11β,16α)-, Pregna-1,4-diene-3,20-dione, 6α,9-difluoro-11β,21-dihydroxy-16α-methyl-, Unii-K253365Dxi

Description

Applications Difluocortolone is used as a topical therapy in the treatment of pediatric tinea corporis; a common mycotic infection in children.
References Veraldi, S., et al.: J. Dermatol. Treat., 29, 200 (2018)

• Brand: TRC

Chemical properties

• Molecular weight: 394.45
• Formula: C₂₂H₂₈F₂O₄
• Color/Form: Off-White To Grey
• InChI: InChI=1S/C22H28F2O4/c1-11-6-13-14-8-16(23)15-7-12(26)4-5-21(15,3)22(14,24)18(28)9-20(13,2)19(11)17(27)10-25/h4-5,7,11,13-14,16,18-19,25,28H,6,8-10H2,1-3H3/t11-,13+,14+,16+,18+,19-,20+,21+,22+/m1/s1
• InChI key: InChIKey=OGPWIDANBSLJPC-RFPWEZLHSA-N
• SMILES: C[C@@H]1C[C@H]2[C@@H]3C[C@H](F)C4=CC(=O)C=C[C@]4(C)[C@@]3(F)[C@@H](O)C[C@]2(C)[C@H]1C(=O)CO