20b-Dihydrocortisol

CAS: 116-58-5

Ref. TR-D448740

Product Information

• Name: 20b-Dihydrocortisol
• Synonyms: Pregn-4-en-3-one, 11,17,20,21-tetrahydroxy-, (11beta,20R)-, Pregn-4-en-3-one, 11beta,17,20beta,21-tetrahydroxy- (6CI,7CI,8CI), (11beta,20R)-11,17,20,21-Tetrahydroxypregn-4-en-3-one, 11beta,17,20beta,21-Tetrahydroxy-4-pregnen-3-one, 11beta,17a,20beta,21-Tetrahydroxy-pregn-4-en-3-one, 17-(1,2-Dihydroxyethyl)androsten-3-one-11,17-diol, 20beta-Dihydrocortisol, 20beta-Hydroxycortisol, 4-Pregene-11beta,17alpha,20beta,21-tetrol-3-one, 4-Pregnene-11beta,17alpha,20beta,21-tetrol-3-one, Pregn-4-en-11beta,17alpha,20beta,21-tetrol-3-one, Pregn-4-ene-11beta,17alpha,20beta,21-tetraol-3-one, Reichstein's compound E, Reichstein's substance E, delta4-Pregnene-11beta,17alpha,20beta,21-tetraol-3-one, Pregn-4-en-3-one, 11,17,20,21-tetrahydroxy-, (11ß,20R)-, Pregn-4-en-3-one, 11ß,17,20ß,21-tetrahydroxy- (6CI,7CI,8CI), (11ß,20R)-11,17,20,21-Tetrahydroxypregn-4-en-3-one, 11ß,17,20ß,21-Tetrahydroxy-4-pregnen-3-one, 11ß,17a,20ß,21-Tetrahydroxy-pregn-4-en-3-one, 20ß-Dihydrocortisol, 20ß-Hydroxycortisol, 4-Pregene-11ß,17a,20ß,21-tetrol-3-one, 4-Pregnene-11ß,17a,20ß,21-tetrol-3-one, Pregn-4-en-11ß,17a,20ß,21-tetrol-3-one, Pregn-4-ene-11ß,17a,20ß,21-tetraol-3-one, ?4-Pregnene-11ß,17a,20ß,21-tetraol-3-one, 17-(1,2-Dihydroxyethyl)androsten-3-one-11,17-diol, Reichstein's compound E, Reichstein's substance E, 11-Beta,17-Alpha-20-Beta,21-Tetrahydroxypregn-4-En-3-One, (11beta,20S)-11,17,20,21-tetrahydroxypregn-4-en-3-one

Description

Applications 20β-Dihydrocortisol could be used as a potential non invasive diagnostic test of transmissible spongiform encephalopaties. 20β-Dihydrocortisol is a metabolite of Cortisol (H714615), a steroid hormone, more specifically a glucocorticoid, produced by the zona fasciculata of the adrenal gland. Cortisol is released in response to stress and a low level of blood glucocorticoids. Its primary functions are to increase blood sugar through gluconeogenesis; suppress the immune system; and aid in fat, protein and carbohydrate metabolism.
References Schelcher, F., et. al.: Endocrinology, 140, 2422 (1999); Phillipov, G., et. al.: J. Clin. Endocr. Metab., 81, 3855 (1996); Vigore, L., et al.: Cancer Ther., 6, 699 (2008); Puurunen, J., et al.: J. Clin. Endocrinol. Metab., 94, 1973 (2009); Lemos, D., et al.: J. Endocrinol., 201, 275 (2009); Chen, S., et al.: Am. J. Physiol., 296 (2009)

• Brand: TRC

Chemical properties

• Molecular weight: 364.48
• Formula: C₂₁H₃₂O₅
• Color/Form: White To Off-White
• InChI: InChI=1S/C21H32O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-18,22,24-26H,3-8,10-11H2,1-2H3/t14-,15-,16-,17+,18+,19-,20-,21-/m0/s1
• InChI key: InChIKey=AWWCEQOCFFQUKS-LCGKLAOVSA-N
• SMILES: C[C@]12C[C@H](O)[C@H]3[C@@H](CCC4=CC(=O)CC[C@@]43C)[C@@H]1CC[C@]2(O)[C@H](O)CO