Dihydroergotamine Mesylate

CAS: 6190-39-2

Ref. TR-D449080

Product Information

• Name: Dihydroergotamine Mesylate
• Synonyms: Dihydroergotamine mesilate, (6aR,9R,10aR)-N-[(2R,5S,10aS,10bS)-5-Benzyl-10b-hydroxy-2-methyl-3,6-dioxooctahydro-8H-oxazolo[3,2-a]pyrrolo[2,1-c]pyrazin-2-yl]-7-methyl-4,6,6a,7,8,9,10,10a- octahydroindolo[4,3-fg]quinoline-9-carboxamide methanesulfonate, Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'α,10α)-, methanesulfonate (1:1), Ergotaman-3',6',18-trione, 9,10-dihydro-12'-hydroxy-2'-methyl-5'-(phenylmethyl)-, (5'α,10α)-, monomethanesulfonate (salt) (9CI), Ergotamine, 9,10-dihydro-, monomethanesulfonate (salt) (6CI,7CI,8CI), 9,10-Dihydroergotamine mesylate, Agit, Angionorm, DETMS, DHE 45, Dergotamine, Diergo, Dihydergot, Dihydroergotamine methanesulfonate, Dihydroergotamine methanesulphonate, Dihydroergotamine monomethanesulfonate, Dihytamine, Dirgotarl, Endophleban, Ergomimet, Ergont, Ergotonin, Ikaran, Migranal, Morena, Orstanorm, Seglor, Tonopres
• Brand: TRC
• Description: Applications α-Androgenic blocker with selective venoconstrictor properties. Also binds to serotonin 5HT1-receptors. Antimigraine.References de Marees, et al.: Eur. J. Clin. Pharmacol., 30, 685 (1986), McCarthy, B.G., et al.: Headache, 29, 420 (1989), Ziegler, D., et al.: Neurology, 44, 447 (1994),

Chemical properties

• Molecular weight: 679.78
• Formula: C₃₃H₃₇N₅O₅·CH₄O₃S
• Color/Form: White To Off-White
• InChI: InChI=1S/C33H37N5O5.CH4O3S/c1-32(35-29(39)21-15-23-22-10-6-11-24-28(22)20(17-34-24)16-25(23)36(2)18-21)31(41)38-26(14-19-8-4-3-5-9-19)30(40)37-13-7-12-27(37)33(38,42)43-32;1-5(2,3)4/h3-6,8-11,17,21,23,25-27,34,42H,7,12-16,18H2,1-2H3,(H,35,39);1H3,(H,2,3,4)/t21-,23-,25-,26+,27+,32-,33+;/m1./s1
• InChI key: InChIKey=ZOZUFVUTVAZUDP-OESQIVJBSA-N
• SMILES: CN1C[C@H](C(=O)N[C@]2(C)O[C@@]3(OS(C)(=O)=O)[C@@H]4CCCN4C(=O)[C@H](Cc4ccccc4)N3C2=O)CC2c3cccc4[nH]cc(c34)C[C@H]21