(E)-(3,4-Dihydro-7-methoxy-1(2H)-naphthalenylidene)acetonitrile

CAS: 178676-65-8

Ref. TR-D450481

Product Information

• Name: (E)-(3,4-Dihydro-7-methoxy-1(2H)-naphthalenylidene)acetonitrile
• Synonyms: (2E)-2-(7-methoxytetralin-1-ylidene)acetonitrile
• Brand: TRC
• Description: Applications (E)-(3,4-Dihydro-7-methoxy-1(2H)-naphthalenylidene)acetonitrile is an intermediate used in the synthesis of (E)-N-[2-(3,4-Dihydro-7-methoxy-1(2H)-naphthalenylidene)ethyl]acetamide(Agomelatine Impurity) (D450485), which is an impurity of Agomelatine (A430000) which is a melatoninergic agonist and selective antagonist of 5-HT2C receptors and used in the treatment of major depressive disorder. Agomelatine Impurity 2References Yous, S., et al.: J. Med. Chem., 35, 1484 (1992), Zhdanova, I., et al.: J. Clin. Endocrinol. Metab., 86, 4727 (2001), Cajochen, C., et al.: J. Pineal Res., 35, 149 (2003),

Chemical properties

• Molecular weight: 199.25
• Formula: C₁₃H₁₃NO
• Color/Form: Neat
• InChI: InChI=1S/C13H13NO/c1-15-12-6-5-10-3-2-4-11(7-8-14)13(10)9-12/h5-7,9H,2-4H2,1H3/b11-7+
• SMILES: COc1ccc2c(c1)/C(=C/C#N)CCC2