1,9-Dihydro-9-[[2-hydroxy-1-[[(4-methoxyphenyl)diphenylmethoxy]methyl]ethoxy]methyl]-2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6H-purin-6-one

CAS: 88110-86-5

Ref. TR-D450808

Product Information

• Name: 1,9-Dihydro-9-[[2-hydroxy-1-[[(4-methoxyphenyl)diphenylmethoxy]methyl]ethoxy]methyl]-2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6H-purin-6-one
• Brand: TRC
• Description: Applications 1,9-Dihydro-9-[[2-hydroxy-1-[[(4-methoxyphenyl)diphenylmethoxy]methyl]ethoxy]methyl]-2-[[(4-methoxyphenyl)diphenylmethyl]amino]-6H-purin-6-one is an intermediate used in the synthesis of Ganciclovir Triphosphate Triethylamine Salt (G235030), which is an inhibitor of hepatitis B virus DNA polymerase and has shown potent antiviral activity against herpes viruses and hepadnaviruses.References Rubsam, L.Z., et al.: Cancer. Res., 59, 669 (1999); Shaw, T., et al.: Hepatol., 24, 996 (1996)

Chemical properties

• Molecular weight: 799.912
• Formula: C₄₉H₄₅N₅O₆
• Color/Form: Neat
• InChI: InChI=1S/C49H45N5O6/c1-57-41-27-23-37(24-28-41)48(35-15-7-3-8-16-35,36-17-9-4-10-18-36)53-47-51-45-44(46(56)52-47)50-33-54(45)34-59-43(31-55)32-60-49(38-19-11-5-12-20-38,39-21-13-6-14-22-39)40-25-29-42(58-2)30-26-40/h3-30,33,43,55H,31-32,34H2,1-2H3,(H2,51,52,53,56)
• InChI key: InChIKey=HUBQSCAIYJNLHI-UHFFFAOYSA-N
• SMILES: COc1ccc(C(Nc2nc(O)c3ncn(COC(CO)COC(c4ccccc4)(c4ccccc4)c4ccc(OC)cc4)c3n2)(c2ccccc2)c2ccccc2)cc1