6,8-Dihydro-7H-pyrrolo[2,3-g]benzothiazol-7-one

CAS: 222036-27-3

Ref. TR-D453658

Product Information

• Name: 6,8-Dihydro-7H-pyrrolo[2,3-g]benzothiazol-7-one
• Synonyms: 6H-Thiazolo[5,4-e]indol-7(8H)-one
• Brand: TRC

Description

Applications 6,8-Dihydro-7H-pyrrolo[2,3-g]benzothiazol-7-one is an intermediate in synthesizing Imidazolo-oxindole PKR inhibitor C16 (PKR Inhibitor) (P572500). It is a drug which acts as a selective inhibitor of the enzyme double-stranded RNA-dependent protein kinase (PKR). It has been shown to effectively inhibit PKR function in vivo and has neuroprotective and nootropic effects in animal studies.
References Jammi, N., et al.: Biochem. Biophys. Res. Commun., 308, 50 (2003); Ingrand, S., et al.: Neurosci. Lett., 409, 192 (2006); Chen, H., et al.: Eur. J. Neurosci., 28, 2003 (2008); Couturier, J., et al.: J. Biol. Chem., 285, 1272 (2010)

Chemical properties

• Molecular weight: 190.22
• Formula: C₉H₆N₂OS
• Color/Form: Neat
• InChI: InChI=1S/C9H6N2OS/c12-8-3-5-6(11-8)1-2-7-9(5)13-4-10-7/h1-2,4H,3H2,(H,11,12)
• InChI key: InChIKey=IMPZLDDOQIAFJH-UHFFFAOYSA-N
• SMILES: O=C1Cc2c(ccc3ncsc23)N1