N-[(1,1-Dimethylethoxy)carbonyl]glycine Methyl Ester

CAS: 31954-27-5

Ref. TR-D472925

Product Information

• Name: N-[(1,1-Dimethylethoxy)carbonyl]glycine Methyl Ester
• Synonyms: (tert-Butoxycarbonylamino)acetic Acid Methyl Ester, BOC-glycine Methyl Ester, Methyl N-(tert-butoxycarbonyl)glycinate, Methyl N-[[(1,1-Dimethylethyl)oxy]carbonyl]glycinate, N-(Carbo-tert-butyloxy)glycine Methyl Ester, N-(tert-Butoxycarbonyl)glycine Methyl Ester, N-Boc-glycine Methyl Ester
• Brand: TRC

Description

Applications N-[(1,1-Dimethylethoxy)carbonyl]glycine Methyl Ester is a amino acid glycine (G615990) derivative, used widely in various synthetic preparations of pharmaceutical goods and antioxidants. N-[(1,1-Dimethylethoxy)carbonyl]glycine Methyl Ester can be used in the preparation of Pregabalin (P704800), a GABA analogue used as an anticonvulsant.
References Ko, E.H., et al.: J. Am. Chem. Soc., 133, 462 (2011); Heller, S.T., et al.: Org. Lett., 12, 4572 (2010); Taylor, C.P., at al.: Epilepsy Res., 14, 11 (1993), Field, M.J., et al.: Pain, 80, 391 (1999)

Chemical properties

• Molecular weight: 189.21
• Formula: C₈H₁₅NO₄
• Color/Form: Neat
• InChI: InChI=1S/C8H15NO4/c1-8(2,3)13-7(11)9-5-6(10)12-4/h5H2,1-4H3,(H,9,11)
• InChI key: InChIKey=PHUZOEOLWIHIKH-UHFFFAOYSA-N
• SMILES: COC(=O)CNC(=O)OC(C)(C)C