N,N'-bis(2,6-Dimethylphenyl)-1,4-piperazinediacetamide

CAS: 380204-72-8

Ref. TR-D477030

Product Information

• Name: N,N'-bis(2,6-Dimethylphenyl)-1,4-piperazinediacetamide
• Synonyms: 2,2'-(Piperazine-1,4-diyl)bis[N-(2,6-dimethylphenyl)acetamide], N1,N4-bis(2,6-Dimethylphenyl)-1,4-piperazinediacetamide
• Brand: TRC

Description

Impurity Ranolazine USP Related Compound D
Applications N,N'-bis(2,6-Dimethylphenyl)-1,4-piperazinediacetamide is an intermediate of Ranolazine (R122500), an anti-ischemic agent which modulates myocardial metabolism. Ranolazine is also known to exert antianginal activities.
References Sampath, A., et al.: Org. Proc. Rsch. Dev., 16, 748 (2012); Chaitman, B.R., et al.: J. Am. Coll. Cardial., 43, 1375 (2004); McCormack, J.G., et al.: Gen. Pharmacol., 30, 639 (1998); Schofield, J.A.H., et al.: Expert Opin. Invest. Drugs, 11, 117 (2002)

Chemical properties

• Molecular weight: 408.54
• Formula: C₂₄H₃₂N₄O₂
• Color/Form: Neat
• InChI: InChI=1S/C24H32N4O2/c1-17-7-5-8-18(2)23(17)25-21(29)15-27-11-13-28(14-12-27)16-22(30)26-24-19(3)9-6-10-20(24)4/h5-10H,11-16H2,1-4H3,(H,25,29)(H,26,30)
• InChI key: InChIKey=FRRCDIZIDLHOOV-UHFFFAOYSA-N
• SMILES: Cc1cccc(C)c1NC(=O)CN1CCN(CC(=O)Nc2c(C)cccc2C)CC1