2,5-Dimethylpyrazine

CAS: 123-32-0

Ref. TR-D478970

Product Information

• Name: 2,5-Dimethylpyrazine
• Synonyms: NSC 49139, 2,5-Dimethyl pyrazine, 2,5-Dimethyl-1,4-diazine, 2,5-Dimethylpyrazin, 2,5-Dimetilpirazina, 2,5-Methyl Pyrazine, Dimethyl-2,5-Pyrazine, Ketine, Nsc 49139, Pyrazine, 2,5-dimethyl-

Description

Applications 2,5-Dimethylpyrazine is used as a reagent in the synthesis of bone-targeted proteasome inhibitors for multiple myeloma (MM). 2,5-Dimethylpyrazine is also used in the preparation of 3-Methyl-2,5-bis-(2-hydroxyethyl)pyrazine (M295340); a degredation product of Clavulanic Acid (C563750) which is a β-lactamase inhibitor, typically added to amoxicillin to increase its effectiveness.
References Agyin, J.K., et al.: Bioorg. Med. Chem. Lett., 23, 6455 (2013); Reading, C. and Cole, M.: Antimicrob. Ag. Chemother., 11, 852 (1977); Ball, A.P., et al.: Lancet, 1, 620 (1980); Brogden, R.N., et al. Drugs, 22, 337 (1981); Haginaka, J. et al.: Chem. Pharm. Bull., 33, 218 (1985)

• Brand: TRC

Chemical properties

• Molecular weight: 108.14
• Formula: C₆H₈N₂
• Color/Form: Neat
• InChI: InChI=1S/C6H8N2/c1-5-3-8-6(2)4-7-5/h3-4H,1-2H3
• InChI key: InChIKey=LCZUOKDVTBMCMX-UHFFFAOYSA-N
• SMILES: Cc1cnc(C)cn1