4',6'-Dinitro-2'-phenoxymethanesulfonanilide

CAS: 51765-56-1

Ref. TR-D480760

Product Information

• Name: 4',6'-Dinitro-2'-phenoxymethanesulfonanilide
• Synonyms: N-(2,4-Dinitro-6-phenoxyphenyl)methanesulphonamide, Nimesulide Imp. A (EP)
• Brand: TRC
• Description: Impurity Nimesulide EP Impurity AApplications 4',6'-Dinitro-2'-phenoxymethanesulfonanilide, is an impurity of the drug Nimesulide (N477500), which is an antiinflammatory agent. Preferentially inhibits COX-2 over COX-1. Suppresses chemical-induced carcinogenesis in mice and rats. Inhibits LPS-induced TNF-alpha production. Not a dangerous good if item is equal to or less than 1g/ml and there is less than 100g/ml in the packageReferences Pairet, M., et al.: Inflamm. Res., 47, S93 (1998), Fukutake, M., et al.: Carcinogenesis, 19, 1939 (1998), Okajima., E., et al.: Cancer Res., 58, 3028 (1998), Azab, A., et al.: Life Sci., 63, 323 (1998)

Chemical properties

• Molecular weight: 353.31
• Formula: C₁₃H₁₁N₃O₇S
• Color/Form: Neat
• InChI: InChI=1S/C13H11N3O7S/c1-24(21,22)14-13-11(16(19)20)7-9(15(17)18)8-12(13)23-10-5-3-2-4-6-10/h2-8,14H,1H3
• SMILES: [N-]=[N+]=NCC(=O)N[C@H](CO)[C@H](O)c1ccc([N+](=O)[O-])cc1