N-[5-(1,3-Dioxolan-2-yl)-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide

CAS: 916480-94-9

Ref. TR-D486558

Product Information

• Name: N-[5-(1,3-Dioxolan-2-yl)-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide
• Synonyms: N-[5-(1,3-dioxolan-2-yl)-4-(4-fluorophenyl)-6-propan-2-ylpyrimidin-2-yl]-N-methylmethanesulfonamide
• Brand: TRC
• Description: Applications N-[5-(1,3-Dioxolan-2-yl)-4-(4-fluorophenyl)-6-(1-methylethyl)-2-pyrimidinyl]-N-methylmethanesulfonamide is an intermediate in the synthesis of S-Demethyl (E)-S-[4-(4-Fluorophenyl)-6-isopropyl-2-(N-methylmethylsulfonamido)pyrimidin-5-ethenyl Rosuvastatin (D231085), which is a dimerized impurity of Rosuvastatin (R700500), a selective, competitive HMG-CoA reductase inhibitor.

Chemical properties

• Molecular weight: 395.448
• Formula: C₁₈H₂₂FN₃O₄S
• Color/Form: Neat
• InChI: InChI=1S/C18H22FN3O4S/c1-11(2)15-14(17-25-9-10-26-17)16(12-5-7-13(19)8-6-12)21-18(20-15)22(3)27(4,23)24/h5-8,11,17H,9-10H2,1-4H3
• InChI key: InChIKey=KNRQCGNZEZNSEG-UHFFFAOYSA-N
• SMILES: CC(C)c1nc(N(C)S(C)(=O)=O)nc(-c2ccc(F)cc2)c1C1OCCO1