DOTA

CAS: 60239-18-1

Ref. TR-D535500

Product Information

• Name: DOTA
• Synonyms: 1,4,7,10-Tetraazacyclododecane-1,4,7,10-tetraacetic acid, 1,4,7,10-Tetra(carboxymethyl)-1,4,7,10-tetraazacyclododecane, 1,4,7,10-Tetraazacyclodecane-1,4,7,10-tetraacetic acid, 1,4,7,10-Tetraazacyclododecane-N,N',N'',N'''-tetraacetic acid, NSC 681107, Tetraxetan, 1,4,7,10-Tetraazacyclododecane-N,N′,N′′,N′′′-tetraacetic acid, 2,2',2'',2'''-(1,4,7,10-Tetraazacyclododecane-1,4,7,10-Tetrayl)Tetraacetic Acid, 2-[4,7,10-Tris(carboxymethyl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid, Dota

Description

Stability Hygroscopic
Applications Bifunctional DOTA conjugates to peptides and has become an established strategy for constructing target-specific metal containing agents including targeted MRI contrast agents and diagnostic and therapeutic radiopharmaceuticals.
References Lewis, M., et al.: Bioconjug. Chem., 9, 72 (1998), Chappell, L., et al.: Bioorg. Med. Chem., 7, 2313 (1999), Prantner, A., et al.: Mol. Imaging, 2, 333 (2003), Allen, M., et al.: Chem. Biol., 11, 301 (2004), Weiner, R., et al.: BioDrugs, 19, 145 (2005), Breeman, W., et al.: Radionuclide Peptide Cancer Therapy, 119 (2006),

• Brand: TRC

Chemical properties

• Molecular weight: 404.42
• Formula: C₁₆H₂₈N₄O₈
• Color/Form: Light Yellow
• InChI: InChI=1S/C16H28N4O8/c21-13(22)9-17-1-2-18(10-14(23)24)5-6-20(12-16(27)28)8-7-19(4-3-17)11-15(25)26/h1-12H2,(H,21,22)(H,23,24)(H,25,26)(H,27,28)