Droloxifene Citrate

CAS: 97752-20-0

Ref. TR-D679200

Product Information

• Name: Droloxifene Citrate
• Synonyms: 3-[(Z)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenylbut-1-enyl]phenol;2-hydroxypropane-1,2,3-tricarboxylic acid, (E)-1-[4'-(2-Dimethylaminoethoxy)phenyl]-1-(3-hydroxyphenyl)-2-phenylbut-1-ene Citrate, (E)-3-[1-[4-[2-(Dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]phenol Citrate (1:1) (Salt), (E)-a-[p-[2-(dimethylamino)ethoxy]phenyl]-a'-ethyl-3-stilbenol Citrate, 3-[(1E)-1-{4-[2-(Dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol 2-hydroxypropane-1,2,3-tricarboxylate (1:1), 3-[(1E)-1-{4-[2-(dimethylamino)ethoxy]phenyl}-2-phenylbut-1-en-1-yl]phenol 2-hydroxypropane-1,2,3-tricarboxylate (salt), 97752-20-0, Droloxifene citrate, Phenol, 3-[(1E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-buten-1-yl]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1), Phenol, 3-[(1E)-1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt), Phenol, 3-[1-[4-[2-(dimethylamino)ethoxy]phenyl]-2-phenyl-1-butenyl]-, (E)-, 2-hydroxy-1,2,3-propanetricarboxylate (1:1) (salt)

Description

Applications Droloxifene is a non-steroidal anti-oestrogen that is structurally related to Tamoxifen (T006000), a drug used to prevent the occurrence of breast cancer in postmenopausal women. Droloxifene has a very high binding affinity to estrogen receptors and is used, similarly to Tamoxifen, to prevent and treat breast cancer.
References Coombes, R., et al.: New Engl. J. Med., 350, 1081 (2004); Geisler, J., et al.: J. Ster. Biochem. Mol. Biol., 55, 193 (1995); Hasmann, M., et al.: Cancer Lett., 84, 101 (1994); Powles, T., et al.: Lancet 352, 98 (1998)

• Brand: TRC

Chemical properties

• Molecular weight: 579.64
• Formula: C₂₆H₂₉NO₂·C₆H₈O₇
• Color/Form: Neat
• InChI: InChI=1S/C26H29NO2.C6H8O7/c1-4-25(20-9-6-5-7-10-20)26(22-11-8-12-23(28)19-22)21-13-15-24(16-14-21)29-18-17-27(2)3;7-3(8)1-6(13,5(11)12)2-4(9)10/h5-16,19,28H,4,17-18H2,1-3H3;13H,1-2H2,(H,7,8)(H,9,10)(H,11,12)/b26-25-
• InChI key: InChIKey=GTJXPMSTODOYNP-BTKVJIOYSA-N
• SMILES: CC/C(=C(/c1ccc(OCCN(C)C)cc1)c1cccc(O)c1)c1ccccc1.O=C(O)CC(O)(CC(=O)O)C(=O)O