Product Information
Name:E-64d
Controlled Product
Synonyms:
- (2S,3S)-3-[[[(1S)-3-Methyl-1-[[(3-methylbutyl)amino]carbonyl]butyl]amino]carbonyl]-2-oxiranecarboxylic Acid Ethyl Ester
- Aloxistatin
- E 64c ethyl ester
- EP 453
- EST
- EST (pharmaceutical)
- Loxistatin
- NSC 694281
Brand:TRC
Description:Applications E-64d is an inhibitor of cathepsins B and L as well as a potential inhibitor of calpain. E-64d has been shown to inhibit lysosomal proteases. E-64d has been used in combination with Prepstatin A to interfere with autolysosomal digestion. E-64d displays neurovascular and neuronal protective effects after focal cerebral ischemia in rats.References Wilcox, D. et al.: Biochem. J., 285, 495 (1992); McGowan, E.B. et al.: Biochem. Biophys. Res. Comm., 158, 432 (1989); Tsubokawa, T. et al.: J. Neurosci. Res., 84, 832 (2006);
Notice:Our products are intended for lab use only. For any other use, please contact us.
Chemical properties
Molecular weight:342.43
Formula:C17H30N2O5
Color/Form:Neat
InChI:InChI=1S/C17H30N2O5/c1-6-23-17(22)14-13(24-14)16(21)19-12(9-11(4)5)15(20)18-8-7-10(2)3/h10-14H,6-9H2,1-5H3,(H,18,20)(H,19,21)/t12-,13-,14-/m0/s1
InChI key:InChIKey=SRVFFFJZQVENJC-IHRRRGAJSA-N
SMILES:CCOC(=O)[C@H]1O[C@@H]1C(=O)N[C@@H](CC(C)C)C(=O)NCCC(C)C
Technical inquiry about: E-64d
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