Product Information
- 1,2,5-Oxadiazole-3-carboximidamide
- 4-[[2-[(aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-
- [C(Z)]-
- [C(Z)]-4-[[2-[(Aminosulfonyl)amino]ethyl]amino]-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,5-oxadiazole-3-carboximidamide
- ICBN 24360
- INCB 024360
Applications Epacadostat is a potent and novel indoleamine 2,3-dioxygenase (IDO1) inhibitor with IC50 of 10 nM. It has high selectivity over IDO2 and tryptophan 2,3-dioxygenase (TDO).
References Yue, Eddy W., et al.: ACS Med. Chem. Lett., 8, 486 (2017);
Chemical properties
Technical inquiry about: TR-E565503 Epacadostat
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